Physical and Chemical Stability of Antibody Drug Conjugates: Current Status
نویسندگان
چکیده
منابع مشابه
Antibody-drug conjugates: current status and future directions.
Antibody-drug conjugates (ADCs) aim to take advantage of the specificity of monoclonal antibodies (mAbs) to deliver potent cytotoxic drugs selectively to antigen-expressing tumor cells. Despite the simple concept, various parameters must be considered when designing optimal ADCs, such as selection of the appropriate antigen target and conjugation method. Each component of the ADC (the antibody,...
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ADC bioanalytical strategies With the US FDA approval of Adcetris® (brentuximab vedotin) in 2011 and Kadcyla® (ado-transtuzumab emtansine) in 2013, antibody-drug conjugate (ADC) has been a hot topic in industry. Because of the complexity of an ADC, combining monoclonal antibody and small molecule toxin, its bioanalysis has seen unprecedented amount of discussion compared to other drug modalitie...
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ژورنال
عنوان ژورنال: Journal of Pharmaceutical Sciences
سال: 2016
ISSN: 0022-3549
DOI: 10.1016/j.xphs.2015.11.037